Mood Changes

Some women find that hormone fluctuations in perimenopause create a feeling of being out of control. Reports of increased irritability, anxiety, fatigue, and blue moods are not uncommon.
For depression, prescription antidepressant medications may be indicated to correct a chemical imbalance. Although several weeks are usually needed to experience the full effect of one of these drugs, many women show a marked improvement with these medications with relatively few side effects. Some antidepressants have also been found to treat hot flashes. Antidepressant therapy is most effective when combined with counseling or psychotherapy.